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A.E. Arbuzov Institute of Organic and Physical Chemistry

Kazan Scientific Centre Russian Academy of Sciences

Laboratory of highly organized structures

The Laboratory of Highly Organized Structures was created on the base of the group under the supervision of Dr. L.A. Kudryavtseva in 2000. Since 2008 the Laboratory is headed by Professor Lucia Ya. Zakharova.

 

Head of Laboratory
Full Professor, Dr. Zakharova Lucia Yarullovna
Phone number (843) 273-22-93
Room 306
Email lucia@iopc.ru

Deputy Head of the Laboratory

Senior Researcher, PhD Mirgorodskaya Alla Bencionovna
Phone number (843) 273-22-93
Room 311
Email mirgorod@iopc.ru

Members and postgraduates
Senior Researcher, PhD Zhiltsova Elena Petrovna
Senior Researcher, PhD Lukashenko Svetlana Sergeevna
Researcher, PhD Valeeva Farida Garafeevna
Researcher, PhD Gaynanova Gulnara Akhatovna
Researcher, PhD Pashirova Tatiana Nikandrovna
Researcher, PhD Ibragimova Alsu Raynurovna
Researcher, PhD Kashapov Ruslan Ravilevich
Junior Researcher, PhD Kudryashova Yuliana Radikovna
Junior Researcher, PhD Gabdrakhmanov Dinar Rashidovich
Junior Researcher, PhD Vasilieva Elmira Albertovna
Junior Researcher, PhD Yackevich Ekaterina Igorevna

 

 

History of the laboratory's development

See photos

 

Laboratory of Highly Organized Structures (LHOS) is historically related to Laboratory of Organophosphorus Polymers (LOPP) under the leadership of Professor B.E. Ivanov, one of the largest and oldest laboratories of the A.E. Arbuzov Institute of Organic and Physical Chemistry (IOPC). Over 1975-1985 period, the laboratory staff comprised over 80 people and gathered leading scientific groups that carried out research on the tasks of the Presidium of the Academy of Sciences of the USSR. Eventually some of these research teams of LOPP branched out into independent laboratories headed by Professor V.S. Reznik, Professor Ya.A. Levin, Professor I.A. Nuretdinov. In 1996 the group of LHOS was separated and taken under the leadership of Dr. L.A. Kudryavtseva. At that time the main focus of the laboratory work was the study of influence of the solvents as well as micellar systems on the rate of nucleophilic substitution reactions of phosphorus acid esters. Dr. V.E. Belskiy and Dr. S.B. Fedorov played a central role in the evolution of laboratory and its creative development. Since 2008 the Laboratory is headed by Professor Lucia Ya. Zakharova.

 

Research trends

  • The main research direction of the LHOS is the development of self-assembly strategies of the design of polyfunctional nanosystems with enhanced properties (catalysis, solubilization, anticorrosion and antimicrobial activity) based on the key “bottom-up” principle of supramolecular chemistry, i.e. non-covalent self-organization of surfactants, cyclophanes, and polymers. One of the priority research lines in the LHOS concerns specifically the formation of nanosized containers and polyelectrolyte capsules for organic and biological substrates in order to identify the factors controlling substrate reactivity, preservation, concentration and biotransport. A new approach to encapsulate hydrophobic (uncharged) substrates was developed using layer-by-layer technology allowing obtaining of micro- and nanocapsules with substrate binding and release properties. Recently the laboratory activity has been concerned with the solution of fundamental problems in medical chemistry, pharmacology, and nanoengineering. From this point of view, our research interest includes the investigation of the novel supramolecular systems that sensitive to external stimuli and capable to effectively interact with cell membranes.
  • The achievement of the goals stated assumes a systematic study of self-assembly of individual amphiphilic compounds and their mixed systems, including their synthesis as a tool for progressive variation of the building block structure. This approach allows us to go from screening to the directed design of functional systems based on established regularities.
  • Biomimetic nature of supramolecular systems allows us to solve the high-priority problems of the biotechnological applications: the formation of nanocontainers, micro- and nanocapsules for storage and delivery of therapeutic agents including water-insoluble drugs, DNA, diagnostic probes.
  • Laboratory pays much attention to the collaboration with research groups working in the key areas of regional science associated with oil extraction and processing. The experience gained and knowledge of the tendency in changes of properties of surfactants in condensed state makes it possible to design the inhibitors of corrosion - bactericides for the protection of oil field equipment and viscoelastic compositions for increasing oil recovery, etc.

Achievements

  • Dynamic supramolecular systems based on oppositely charged calix[4]resorcinarene and surfactant with novel mechanism of binding and release of “guests” to and from the hydrophobic pocket have been designed. The single surfactant molecules self-assemble into aggregates, which bind the organic substrates and release them under the action of calix[4]resorcinarene. The transition from traditional surfactants to the mixed compositions with oppositely charged calix[4]resorcinarene allows to create a new type of nanocontainers with controlling binding/release functions toward hydrophobic molecules.
  • Novel nanosized capsules (≤200 nm) have been obtained by layer-by-layer adsorption of polyelectrolytes on dispersed substrates (water-insoluble esters, probes-dyes and fluorescent europium complexes). Layer-by-layer protocol ensures the high functional stability of compounds encapsulated, does not require the use of auxiliary matrices and allows controlling the rate of substrate release.
  • New pH-dependent nanocontainers based on nonionic surfactants and amphiphilic pyrimidinophanes for controllable drug delivery have been constructed. Nanocontainer structure and binding/release of hydrophobic substrates are controlled by the acid-alkaline balance of the environment and are due to pyrimidinophane capability to change its conformational state.
  • Novel DNA transfer agents based on cationic surfactants with pyrimidine, diterpenoid and hydroxyethyl moieties have been designed that exhibited advanced biocompatibility, high transfection efficiency and relatively low toxicity. These nanocarriers are recommended for further biomedical study (collaborative research and development with other specialized laboratories of IOPC, Kazan Institute of Biochemistry and Biophysics, Novosibirsk State University).

Selected Publications

 

Grants Support

 

Collaborations with other Institutes and Centers

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Laboratory Equipment